Drug-Induced Hypersensitivity Reaction and Re-Introduction of Anti-Tubercular Drugs (ATT): A Case Report and Review of Literature
نویسندگان
چکیده
Tuberculosis (TB) is a communicable disease caused by the bacillus Mycobacterium tuberculosis and leading cause of death single infectious agent overall. According to WHO Global TB Report, India contributes 26% global burden TB. Currently, four-drug regimen comprising Rifampicin, Isoniazid, Pyrazinamide, Ethambutol approved for treatment drug-sensitive The management cutaneous adverse drug reactions anti-tubercular drugs akin double-edged sword, with discontinuation ATT increasing risk developing disseminated drug-resistant tuberculosis, continuation persistence or exacerbation reaction (ADR). an ADR therapy (ATT) varies from 8 85% in various studies [10]. prevalence rashes associated shows that maculopapular rash (42.5%) most frequently observed type, followed urticarial, lichenoid, DRESS, AGEP, exfoliative dermatitis (17). Cutaneous ADRs lowest highest are Ethionamide, Cycloserine, Ethambutol, Para-aminosalicylic acid (PAS), Streptomycin (25). We present case approach re-introduction first-line after hypersensitivity fixed-dose combinations.
 Keywords: Tuberculosis, reaction,
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2023
ISSN: ['2250-1177']
DOI: https://doi.org/10.22270/jddt.v13i6.6080